A TRAIL of destruction

Regulating the TRAIL of destruction: how A20 protects glioblastomas from TRAIL-mediated death.

In this issue of Cancer Discovery, Bellail and colleagues unravel how overexpression of the ubiquitin-modifying enzyme A20 results in TNF-related apoptosis-inducing ligand (TRAIL) resistance in glioblastoma. After TRAIL receptor stimulation, A20 mediates the polyubiquitination of RIP1 at the TRAIL receptor tail, resulting in the interaction of the polyubiquin chain to procaspase-8 that is recru...

Archaeology. Militants leave trail of destruction at Iraqi sites.

Apo2L/TRAIL inhibits tumor growth and bone destruction in a murine model of multiple myeloma.

PURPOSE Multiple myeloma is an incurable disease, for which the development of new therapeutic approaches is required. Here, we report on the efficacy of recombinant soluble Apo2L/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to inhibit tumor progression and bone destruction in a xenogeneic model of human multiple myeloma. EXPERIMENTAL DESIGN We established a mouse model of ...

Apoptosis and autoimmune thyroid disease: following a TRAIL to thyroid destruction?

In the past decade, it became apparent that immune mediated cell death in a number of autoimmune endocrine diseases was due to the induction of apoptosis in target organ cells. This was conclusively demonstrated for thyroid follicular cells in Hashimoto's (destructive autoimmune) thyroiditis, but the mechanisms underlying this cell death were not clear. Several hypotheses were put forth involvi...

Evaluation of Antiplaque Efficacy of a Propolis-Based Herbal Toothpaste: A Single-Blind Parallel Clinical Trail

Background and Aim: In recent years, the use of herbal oral care products has been taken into consideration for reducing dental plaque accumulation. Propolis has been widely used in medicine due to its multiple biological properties. The aim of this study was to evaluate the antiplaque efficacy of an herbal toothpaste containing propolis in comparison with a control group. Materials and Method...